Coming of Age: Targeting Cyclin K in Cancers

نویسندگان

چکیده

Cyclins and cyclin-dependent kinases (CDKs) play versatile roles in promoting the hallmarks of cancer. Therefore, cyclins CDKs have been widely studied targeted cancer treatment, with four CDK4/6 inhibitors being approved by FDA many other examined clinical trials. The specific purpose this review is to delineate role therapeutic potential Cyclin K cancers. Studies shown that regulates essential biological processes, including DNA damage response, mitosis, pre-replicative complex assembly, critical both cell growth resistance. Importantly, druggability has demonstrated an increasing number studies identify novel opportunities for its use treatment. This first introduces basic features translational value human CDKs. Next, discovery, phosphorylation targets, related functional significance K-CDK12/13 complexes are detailed. then provides a summary current K-associated studies, emphasis on available K-targeting drugs. Finally, knowledge gaps regarding cancers discussed, along interesting directions future investigation.

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ژورنال

عنوان ژورنال: Cells

سال: 2023

ISSN: ['2073-4409']

DOI: https://doi.org/10.3390/cells12162044